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10.1016/j.freeradbiomed.2017.10.379 13 ChengY.SongY.ChenH.LiQ.GaoY.LuG.et al (2021)

DNA damage induced by free radicals includes base modifications, strand breaks, and cross-linking

They found that in NRF-2/PGC-1 dKO mice, there is elevation of various autophagosomal markers (p62/SQSTM1, Beclin-1 and LC3B) along with the increased levels of microglia marker, Iba1 and accumulation of oxidative stress markers (4-HNE) and endoplasmic reticulum stress markers (GRP78 and ATF4