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Healthy cells dynamically recruit chaperones, activate stress responses, mobilize UPS function, and initiate autophagy and mitophagy as integrated responses to stress

Psychostimulants (METH, cocaine and synthetic cathinones) induce neurotoxicity primarily through disruption of monoaminergic signaling

Under normal conditions, the antioxidant defence systems are probably capable of maintaining a low steady-state level of damage and thus protecting the cells (Zhou et al.2003)

However, retinoids can be taken constantly [254]

Disulfiram metabolites, including diethyldithiocarbamate (DDC), carbon disulfide (CS2), S-methyl N,N-diethylthiocarbamate sulfoxide (DETC-sulfoxide), S-methyl N,N-diethylthiocarbamate sulfone (DETC-sulfone), diethylthiomethylcarbamate, S-methyl-DDC, methyl diethylthiocarbamate sulfoxide, and methyl diethylthiocarbamate sulfone, play a crucial role in its pharmacological effects (PharmGKB, 2023)