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This area tends to swell and hold onto water, with illnesses, allergies, or even just lack of sleep - and all that changing in volume stretches out and damages the skin in a way that becomes irrepairable over time

[DOI] [PubMed] [Google Scholar] 23.Berg R.L., Shaw G.R

Although our experience suggests that hydroxocobalamin does not cause clinically significant interference with non-invasive pulse oximetry, there is evidence to suggest that co-oximetric blood gas analysis with several unique analyzers may be altered in the presence of hydroxocobalamin, specifically with false elevations of carboxyhemoglobin and methemoglobin concentrations and underestimation of true oxygen saturation values.5 There is no available evidence regarding the accuracy of other commonly utilized oximetric monitoring modalities (e.g., cerebral oximetry) following hydroxocobalamin administration

10.1016/j.semcdb.2011.05.005 [DOI] [PubMed] [Google Scholar] 24