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Description

recurrentis 15 (TP inactivation) were chosen

Thyroid (1998) 8:88794

Mitochondria-targeted antioxidants: a step towards disease treatment

Following the above general procedure C, the reaction was purified by flash-column chromatography on silica gel to provide the desired ethyl 4-(adamantylamino)-3-(pyrimidin-5-ylmethylamino)benzoate (SRS16-41, Scheme 3) (80 mg, 0.197 mmol, 80%)

Specifically, DIO1 has a bidirectional effect on thyroid hormones: it can promote the conversion of low bioactive T4 to highly bioactive T3 and facilitate the conversion of highly bioactive T3 to low bioactive DIT [110]