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A total of 138 patients with clinically definite MS, measurable disability on Guys neurological disability scale (GNDS), without relapse in the preceding 6 months and without antidepressant drugs prescription were enrolled

The TurboIonSpray source operated under positive ion mode at a voltage of 5500 volts and with a turbo gas flow of 10 l min 1 of air heated to 450 C (nominal heating-gun temperature)