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These copper-dependent enzymes include cytochrome c oxidase, superoxide dismutase, and various oxygenases and oxidases such as tyrosinase, lysyl oxidase, dopamine beta-hydroxylase, and copper amine oxidase (53)

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To determine whether the TFG motif is critical for LSM14 localization, we used immunofluorescence microscopy to examine the subcellular localization of FLAGtagged wildtype and mutant LSM14 proteins in HeLa cells depleted of endogenous LSM14

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