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This metabolism is determined by genetic factors and movement

In response to oxidative stress, cGAS activation via STING drives the expression of senescence-associated secretory phenotype (SASP) factors, including TNF-, IL-6, CXCL2, CXCL10, CCL3, and CCL5

J Int Soc Sports Nutr 12, 27 (2015) doi:10.1186/s12970-015-0086-7 Luiking, Y

Concurrently, lactate induces polarization of helper T (Th) and CD4+ T cells, fostering an immunosuppressive environment that suppresses Th1 subsets critical for antitumor activity (17)