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The existing body of evidence is largely limited to small-animal studies, characterized by heterogeneous delivery methods and a lack of standardized dosing or long-term safety data

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however, when there are a large number of phospholipids, the space inside the micelle becomes larger and can trap water in direct contact with the hydrophobic tails (Figure 6C), rendering the micelle unstable

J Exp Nanosci 9:582587 Liu CL, Wu HT, Hsiao YH et al (2011) Insulin-directed synthesis of fluorescent gold nanoclusters: preservation of insulin bioactivity and versatility in cell imaging