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doi:10.1111/j.1420-9101.2006.01091.x

Generally, whether the substance does not absorb radiation over 290 nm, direct photodegradation under solar radiation cannot occur, because of absorptive properties of the ozone layer (Tonnesen 2004)

Cao S, Yan B, Lu Y, Zhang G, Li J, Zhai W, Guo W, Zhang S

Combining modalities for example, pairing cosmelan depigmentation peels with brightening IV drips can address both surface-level pigmentation and deeper dermal melanin deposits, advancing overall rejuvenation more comprehensively than single-modality approaches

Its use requires vigilance for adverse effects, most notably potential hepatotoxicity, which necessitates regular monitoring of liver function