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Activation of TRPV1 restored GPX4 levels, reduced lipid peroxidation, and improved cartilage integrity in both IL-1treated chondrocytes and OA mouse models ( These findings highlight the importance of considering cellular heterogeneity in ferroptosis regulation and suggest that targeting ferroptosis in a subpopulation-specific manner may enhance therapeutic precision in OA

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In this case, the interaction of the reduced glutathione with the sulfene group first leads to the appearance of a mixed disulfide formed by the protein and glutathione: Pt-SOH + GSH PtS-SG + 2 and then to the reduction of the thiol group of the protein PtS-SG + GSH Pt-SH + GSSG The importance of the reduction reaction of thiol groups of proteins with glutathione is explained by the fact that the formation of sulfene ionic groups in the molecules of a number of proteins that regulate the phenotypic properties of cells changes the properties of these proteins

Pro-inflammatory cytokines were supposed to alter the activity of ceramide-metabolizing enzymes, thereby changing the ceramide composition of the skin and further leading to skin barrier damage (124)

Zeng Z, Samudio IJ, Munsell M, An J, Huang Z, Estey E, Andreeff M , Konopleva M