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Consequently, dehydrated and non-deformable cells exhibit a high susceptibility to hemolysis, with clinical symptoms varying from compensated anemia to transfusion dependency (1, 17, 35)

In contrast, BsADCs enhance payload delivery through two primary strategies: (B) A biparatopic BsADC induces receptor clustering and robust internalization by binding two distinct epitopes on the same tumor-associated antigen

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Expression of PKM2 in cancer has been suggested to enhance proliferative metabolism by causing a backflow of metabolites into anabolic pathways such as the serine biosynthesis pathway 8