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This bioenergetic crisis induces ferroptosis via iron-mediated lipid peroxidation and caspase-independent apoptosis through AIF release, culminating in tumor cell death even without therapeutic intervention ( 2.2.2 The connection between mitophagy and tumor cell metabolism Mitophagy is intricately linked to the metabolic reprogramming that occurs in cancer cells

Curr Neurol Neurosci Rep 13:394

In this situation glutathione is no longer available in the affected cells by normal production and an exogenous, that is an outside supply is required

StatPearls Publishing, Treasure Island (FL) Zhang K, Dai Z, Zhang W, Gao Q, Dai Y, Xia F, Zhang X (2021) EDTA-based adsorbents for the removal of metal ions in wastewater