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Infection usually begins with an expanding skin lesion, known as erythema migrans (referred to as stage 1), which, if untreated, can be followed by early disseminated infection, particularly neurological abnormalities (stage 2), and by late infection, especially arthritis in North America or acrodermatitis chronica atrophicans in Europe (stage 3)

CNS Drugs (2014) 28:110

Treatment response cannot be judged by nausea, constipation or appetite changes alone

The pigeon has a well-developed ability to detect weak vibrations (Shen 1983)

Interestingly, IGF-1 infusion suppresses GHRH-induced GH release in males but not in females, suggesting a sexually dimorphic effect (450)