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The sequential clinical presentation of smallpox, starting from exposure, to asymptomatic viral replication with two early viremias, to prodroma, to rash, and then to complications, or recovery, or demise reveals unique stepwise pathogenesis: blocked initial host defense cellular reactions accompanied by unimpeded and asymptomatic viral replication with viremias, and later on, cascades of severe unregulated inflammatory reactions, localization of adherent Variola-laden leucocytes within dermal capillaries, leucocyte diapedesis from the capillaries to infect the skin, destructive rash, toxemias, circulating immune complexes with soluble Variola antigens, and complement activation, among others

doi: 10.1152/ajpgi.00072.2010 6 BlumbergR.ChoJ.LewisJ.WuG

doi: 10.1097/GME.0000000000002028

Search terms included artemisinin, artesunate, dihydroartemisinin, artemether, artemisinin dimer, sodium artesunate, lung, pulmonary fibrosis, pulmonary nodules, tuberculosis, lung cancer, pneumonia, lung injury, chronic obstructive pulmonary disease

10.26554/sti.2017.2.4.102-104 [Google Scholar] Moradi S, Ziaei R, Foshati S, Mohammadi H, Nachvak SM, Rouhani MH (2019) Effects of Spirulina supplementation on obesity: a systematic review and meta-analysis of randomized clinical trials