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Packer (Eds.), Methods in enzymology (Vol

Although novel therapeutic strategies and targeted therapies, including intraperitoneal administration, poly (ADP-ribose) polymerase (PARP) inhibitors, and anti-angiogenic agents, have been introduced, the five-year survival rate for patients with advanced ovarian cancer (OC) remains approximately 30%

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Oxygen sensing and the molecular stratagems underlying the process have been the focus of an endless number of investigations trying to find an answer to the question: "What is the identity of the oxygen sensor?" Dynamic changes in p O 2 constitute a potential signaling mechanism for the regulation of the expression and activation of reduction-oxidation (redox)-sensitive and oxygen-responsive transcription factors, apoptosis-signaling molecules and inflammatory cytokines

Zawada, A