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Precisely how H4R and the release of these mediators are connectedeither directly or indirectlyas well as the identity of the H4R-bearing cell (discussed further below) remains to be determined

5.2.1 Key antioxidant pathways in ferroptosis regulation In critical oxidative stress response pathways, Nrf2/HO-1 signaling is paramount, with Nrf2 serving as a key endogenous antioxidant factor

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doi: 10.1038/s41593-018-0334-7 9 MllerNMyintAMKrauseDWeidingerESchwarzMJ