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These strategies underscore the potential to therapeutically target the microbiota-BA-immune axis, but also highlight the need for personalized approaches considering individual host-microbe-diet interactions and tumor-specific contexts (explored in Section 4.1)

The administration of ototoxic drugs or exposure to loud noise enhances glutamate secretion in the IHCs

In this context, natural compounds such as polyphenols have emerged as promising candidates due to their multifaceted mechanisms of action, including antioxidant, antiinflammatory, and neuroprotective properties