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Multiple uremic toxins have been identified as inducers of eryptosis, including indoxyl sulfate (IS) (Voelkl et al., 2013), acrolein (Fller et al., 2008b), and indole-3-acetic acid (IAA) (Gao et al., 2015) as listed in Table 1

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One important reason is that DTP cells can survive under the action of chemotherapeutic drugs and enter a low proliferation state, just like embryos in diapause, thereby evading drug killing (39, 51, 52)

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