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Modest pain relief may take several months

In severe cases, oxygen therapy is required

During fetal and early postnatal life, adequate maternal thyroid hormone supply is critical for neurogenesis, neuronal migration, synaptogenesis, and myelination ( The entry of thyroid hormones into the central nervous system depends on specialized transporters at the BBB ( Within the brain, deiodinase enzymes modulate local hormone availability ( At the cellular level, thyroid hormones act through nuclear receptors TR and TR to regulate transcription of genes involved in neuronal metabolism, mitochondrial biogenesis, and cytoskeletal organization ( 3.2 Hypothyroidism and central nervous system dysfunction Hypothyroidism affects the central nervous system in ways that extend beyond metabolic slowing

Trends in Food Science & Technology, 163 , Article 105106

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