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In adipocytes, NNMT inhibition elevates NAD and SAM and suppresses de novo lipogenesis in a concentration-dependent manner, consistent with on-target activity [13]

It has to distinguished that the replacement therapy should be only undertaken to restore the physiological levels, never to exceed physiological ranges

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Cognitive and Neurological Benefits Nicotinamide N-methyltransferase (NNMT) inhibition is linked to improved cellular energy, which could support brain function