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Dysregulation of these pathways contributes profoundly to autoimmune pathogenesis by impairing the clearance of damaged organelles and intracellular debris, promoting chronic inflammation, and sustaining autoreactive immune responses

In the GI environment, probiotics counteract harmful microorganisms by shortening GI transit time, limiting opportunities for pathogen colonization, and stimulating the production of bioactive metabolites, such as short-chain fatty acids (SCFAs), which lower colonic pH

To examine the origin of virulence of these fungal pathogens, we compared genomes of classic systemic, opportunistic, and non-pathogenic species, including Emmonsia and two basal branching, non-pathogenic species in the Ajellomycetaceae, Helicocarpus griseus and Polytolypa hystricis

have shown that human colonic microorganisms can also methylate arsenic in arsenic-contaminated soils in vitro

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