glycine and glutathione pathways Mode of action of Amino acid Precursors (GAP) functions Disorder of Glutathione Metabolism |

Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ: Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death

Toxicology studies have shown no lethal dose (LD1) could be achieved in animal models, suggesting a wide therapeutic window

Mice were fed a tamoxifen citrate containing diet for three weeks following the protocol of Kiermayer et al .40 to delete Gpx4

These directions are the core support for translating the hypothesis from theory to application and directly determine whether the gut microbiota-ferroptosis axis mechanism can become a breakthrough framework and intervention target in the study of the gut-joint axis in OA (Figures 2, 3)