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DHT-inducible DKK1 produced by balding DP cells promotes apoptosis of neighboring follicular keratinocytes in vitro, together with the higher expression of DKK1 in balding compared with the haired scalp, suggesting that DKK1 may be one of the key factors involved in the pathogenesis of AGA 41

In addition, Hcy activated the PI3K/AKT/mTOR signaling pathway by inhibiting miR-145 expression, inducing VSMC proliferation, migration, and transformation to a synthetic phenotype

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