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In a notable double-blind trial, older adults with mild cognitive impairment who took Lions Mane extract daily for 16 weeks showed significantly better cognitive scores than those on placebo

Statistical significance was assessed using two-tailed paired t-tests

A 6-week clinical trial using fluoxetine as a positive control found that oral administration of CU at a dose of 1,000 mg/day produced effects comparable to those of 20 mg/day fluoxetine, with response rates on the 17-item Hamilton Depression Rating Scale (HAM-D17) exceeding 60% for both treatments, significantly outperforming placebo (12.5%51.8%) (Sanmukhani et al., 2014)

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In one study, 149 people with recurrent kidney stones were treated with 100 mg three times daily of magnesium oxide plus 10 mg once daily of vitamin B6 for 4.56 years