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Wang, J., Jiang, M., Chen, X

10.1016/j.brainres.2004.11.014 Brain Res

The ASCENT trial has indicated extended OS and consequently brought hope to patients with few remaining therapeutic options 134,135

doi: 10.1016/j.foodchem.2018.11.116 139

Whilst K6 and K37 showed no isoform specificity (Supplementary Table 2), Affimer K3 demonstrated a degree of isoform specificity, with weaker inhibition of HRAS and no measurable inhibition of NRAS with IC 50 values of 144 94 nM for KRAS, 2585 335 nM for HRAS and not obtainable for NRAS, respectively