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10.1007/s12640-022-00534-2 200 RosengrenA.SmythA.RangarajanS.RamasundarahettigeC.BangdiwalaS

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Inflammation Early in vitro studies have documented that plasma proteins, especially albumin, activated the NF-B pathway in cultured proximal tubular cells leading to the production of pro-inflammatory molecules, such as MCP-1, regulated upon activation, normal T cell expressed and secreted (RANTES), IL-8, and fractalkine ( in vitro and in a rat model of proteinuric nephropathy have suggested that excessive cubilin/megalin-mediated albumin uptake by proximal tubular cells overwhelmed lysosomal degradation activity leading to lysosomal rupture and release of hydrolases, especially cathepsin B, which trigger NLRP3 activation ( In addition to soluble cytokines, extracellular vesicles carrying functional cargoes, including exosomes and microvesicles, have emerged as critical mediators in the transmission of albumin-induced inflammatory signals from tubular epithelial cells to macrophages

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J Pain Symptom Manage 19(2):118-29, 2000