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THC exposure has been shown to stimulate the growth of the ER+ MCF-7 cell line (195) and can lead to increased growth and metastasis of tumors with little or no expression of cannabinoid receptors due to suppression of the antitumor immune response (176)

In infected cells, Nox4 gene expression was associated with activation of PI3K/AKT signaling [92]

demonstrated that the inhibition of glycolysis strongly reduced the early phase of the oxygen consumption rate (as readout of the oxidative burst) and ROS release in mouse bone marrow-derived neutrophils stimulated with PMA, while inhibition of mitochondrial respiration impacted to a small degree late-phase ROS release (Furukawa et al., 2000

E.MolonyC.ChudinE.HaoK.YangX.LumP

Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence