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The first clinical use of alpha-lipoic acid was reported in 1959 in Germany, initially for treating Amanita mushroom (death cap) poisoning

doi: 10.1038/nrdp.2017.18 3 Al MamunA.WuY.MonalisaI.JiaC.ZhouK.MunirF.et al

Neurobehavioral examination showed amnestic type cognitive impairment and depression

Pathway analysis of RNAseq data from organs and tumors demonstrated substantial induction of the NRF2 regulon in the lung, kidney, heart, and liver, in particular genes involved in redox homeostasis, but only a weak response in tumors (Fig