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However, challenges such as metabolic side effects and short half-life necessitate innovative delivery strategies, including Pegylation and gene therapy, to optimize its clinical application

Cell 149, 274293, 10.1016/j.cell.2012.03.017 (2012)

The results of their present meta-analysis showed a pooled clinical response rate of 83.3% when HBOT was used as an adjunct to standard therapy in active ulcerative colitis

10.1021/acscentsci.9b00021

We would speculate that ATM is part of a larger cohort of proteins that are tightly regulated to cope with elevated ROS levels and that together they contribute to protecting melanocytes from oxidative stress and ensure their survival within the hair bulb