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If the calf was healthy, it was either left to suckle colostrum directly from the dam, with intake confirmed by observation of active suckling behaviour and evidence of udder emptying, or was separated and fed 12 L of frozen colostrum or 300500 g of colostrum replacer (CR) using either a bottle or an oesophageal tube feeder, depending on individual farm protocol

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in the presence of DMSO) at all tested doses were then ascertained

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