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Weinstock LB, et al

ROS are a hallmark of oxidative stress and they can damage intracellular proteins, lipids, and DNA, leading to impairment of cellular function and structure, which has been implicated in the development of a variety of diseases including aging, diabetes mellitus, vascular endothelial cell injury, neurodegenerative diseases, and the onset of cellular senescence, strategies to replenish depleted NAD + pools can offer significant improvements of pathologic states (Klimova and Kristian, 2019

Rienzo, M

Magnetic resonance imaging (MRI) in September 2016 revealed bilateral degeneration of the forearm proximal tendons and degenerative changes of the neck muscles, with progression of these changes shown in the study of March 2018 (Figure 1)

Certo M, Endo Y, Ohta K, Sakurada S, Bagetta G, Amantea D