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(PubMed) van Uffelen JG, Chinapaw MJ, van Mechelen W, Hopman-Rock M

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To match the peak steady-state concentration, the loading dose can be calculated from equation (13): TARGET CONCENTRATION INTERVENTION: APPLICATION OF PHARMACOKINETICS & PHARMACODYNAMICS TO DOSE INDIVIDUALIZATION The basic principles outlined above can be applied to the interpretation of clinical drug concentration measurements on the basis of three major pharmacokinetic variables: absorption, clearance, and volume of distribution (and the derived variable, half-life)

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GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2