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doi: 10.6061/clinics/2015(08)07

For intravenous vitamin B12, the usual dose is between 500 mcg and 1 mg

Thompson et al., 2019)

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The slightly greater HMOX1 induction by heme compared with heme-HPX is because the rate of heme diffusion into cells is significantly faster than the gradual, relatively slow and safe heme delivery via heme-HPX endocytosis (Smith and Morgan, 1981)