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In mammalian cells, ER stress leads to an integrated stress response involving the related transmembrane kinases Ire1, Ire1 and PKRlike ER kinase (PERK), and the transmembrane activating transcription factor 6 (ATF6) (Zhang & Kaufman, 2004)

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Beyond the glutamate system, ketamine interacts with a range of other sites, including opioid receptors, albeit with lower affinity than with the NMDA receptor 15,16

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While its potential as a systemic anti-aging therapeutic is heavily discussed in longevity circles, the optimal delivery method to target the central nervous system has remained speculative