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Benzo Withdrawal Phases Benzodiazepine withdrawal may occur in three main phases: early withdrawal, acute withdrawal, and protracted withdrawal

Sanyal et al

International journal of sport nutrition and exercise metabolism, 29 (2), 106-116

Treating RPE cells with the iron chelator deferoxamine (DFO) can lead to a reduction in intracellular iron ions (154), an increase in genes related to iron transport, a significant elevation in the level of hypoxia-inducible factor HIF2, and impairment of mitochondrial function, indicating that the RPE is the main target tissue for DFO toxicity, resulting in atrophy and degeneration of the RPE and posing a risk of retinal detachment

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