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In fructose-fed rats, kefir administration for six weeks (1 mL/100 g/day) enhanced hepatic insulin signalling via the peNOS/IRS-1 pathway (Akar et al., 2021)

Scand J Clin Lab Invest

Notably, the upregulation of IL-1 leads to acetylation at lysine (K) 1042 of nicotinamide nucleotide transhydrogenase (NNT) (NNT K1042ac), ensuring the stability of iron-sulfur clusters