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Since changes in intracellular Ca2+ elicited by hyper or hypocalcemia depend on the expression and activity of the CaSR, any decrease explains, at least in part, an impaired intracellular calcium response to [Ca2+e] and hence a reduced inhibitory effect of the cation on PTH secretion

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T., and Rahman I., Circadian Clock Function Is Disrupted by Environmental Tobacco/Cigarette Smoke, Leading to Lung Inflammation and Injury via a SIRT1BMAL1 Pathway, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 28, no