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Following endocytosis, the HoloTC complex is degraded in lysosomes and free B12 is released into the cytoplasm, via CblF (Rutsch et al., 2009) and CblJ ( This free cytoplasmic B12 undergoes a series of intracellular transport and modifications to enable two core enzymatic reactions: 1) adenosyl-B12 acts as a co-factor for the enzyme methylmalonyl-coA mutase that catalyzes the conversion of methylmalonyl-coA to succinyl-coA, thereby enabling restoration of tricarboxylic acid (TCA) cycle intermediates and 2) methyl-B12 enables methionine synthase in the re-methylation of homocysteine to methionine using methyl-tetrahydrofolate (MTHF) as a methyl donor, thereby enabling the vital biochemical pathways of the folate cycle and methionine cycle, facilitating the downstream synthesis of important compounds like DNA and RNA (Figure 2)

& West, J

Accumulated waste is degrading natural habitats and polluting the soil around the palms, threatening tree growth and longterm productivity, Bawahidi said

Moreover, emerging research suggests another avenue through which tocotrienols may operate, involving Peroxisome Proliferator-Activated Receptors (PPARs) (Hassan et al., 2021, Szewczyk et al., 2021)

This suggested that the SlUGT gene family played an important role in plant detoxification, which might be regulated by glutathione