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Moreover, FA injection induced severe inflammation, indicated by increased release of pro-inflammatory cytokines tumor necrosis factor (TNF)- and IL-1, as well as infiltration of macrophage, which can be alleviated by LA supplementation

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PHDs altered the expression of Akt (Guo et al., 2016), centrosomal protein Cep192 (Moser et al., 2013) and FOXO3a (Zheng et al., 2014) to regulate cell proliferation and viability, and showed their potential contribution to tumor development and metastasis via the changes of F-actin (Luo et al., 2014), NFB (Di Conza et al., 2017) or ACC2 (German et al., 2016)

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