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UA also impedes mechanisms of drug resistance, particularly through the inhibition of ABCG2-mediated drug efflux, thereby increasing the effectiveness of chemotherapy agents

Despite prompt adequate intensive support, the conditions deteriorated leading to early death

This shift may alter the absorption of many drugs, by for example increasing the ionization of weak acids like aspirin, which reduces their absorption

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Published research protocols most commonly cite doses between 100300mcg/kg body weight per administration for rodent models, administered once daily via subcutaneous injection