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Melatonin also can increase cell migration and downregulate pro-apoptotic proteins caspase-3, caspase-9, cytochrome c (Cyt C), and B-cell lymphoma-2 assaciated X protein (Bax), but upregulate anti-apoptotic protein B-cell lymphoma-2 (Bcl-2) to against Hcy-induced ECs apoptosis (130)