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Feature · Product Review
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Description

In patients with renal dysfunction, peak concentrations of metabolites 4'-hydroxy- and 5-hydroxy-diclofenac were approximately 50% and 4% of the parent compound after single oral dosing compared to 27% and 1% in normal healthy subjects

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Occasionally, degradation creates compounds with different receptor interactions than the parent peptide

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Nature Communications 7:11190

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In the past, the Schilling test was used, but is rarely conducted today because this test uses radioactive B12

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