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However, prolonged or excessive UPR activation shifts to pro-apoptotic signals, contributing significantly to -cell apoptosis, loss of -cell mass, and reduced insulin synthesis in both T1DM and T2DM

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Secondly, although we measured a series of plasma concentrations of TMAO and its precursors, the measurements were performed only once in the first trimester, making it impossible to assess their dynamic changes throughout the entire pregnancy