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When GHRP-2 binds to GHSR-1a in the hypothalamus, it is theorized to trigger a signal transduction cascade that could lead to increased production of the hunger-inducing neuropeptide, Neuropeptide Y (NPY), and Agouti-related peptide (AgRP), both of which are believed to play significant roles in energy homeostasis and appetite regulation

Feng R, Xiong Y, Lei Y, Huang Q, Liu H, Zhao X, et al

Like replicative senescence or oncogene-induced senescence, TIS displays the common pattern of proliferative arrest, characteristic flat morphology and enlarged cell size, and increased senescence-associated beta-galactosidase (SA- -Gal), reflecting accumulation of GLB1, 11 an endomembrane-localized glycolipid processing enzyme

2a, b and 8

Kaliner, M., Sigler, R., Summers, R