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Because NAC contributes to glutathione production, it is often discussed in relation to liver health

In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)

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Kettring prize

An increase in cAMP secondary to HCO 3 - influx (via HCO 3 - /Na + transporter) was observed in cultured astrocytes and in brain slices