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The JAK/STAT signaling pathway, as the main target for inhibiting the action of a variety of cytokines (221), is involved in the signal transduction of many key cytokines for the pathogenesis of RA and has been considered as a potential target for the treatment of RA (222)

(4) utility difficulties

Endosomes Membrane-bound intracellular vesicles that sort internalized cargo from the plasma membrane and direct it towards recycling, degradation or other trafficking routes

Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBP

They are rarely tested in large human studies, and small short-term studies do not provide strong evidence 16