Practical implication If the clinical picture suggests complex connective tissue remodeling, using one peptide alone can underperform
Disclosures: Fatima DAHBOUL: Nothing to Disclose, JIHAN SUN: Nothing to Disclose, Benjamin Buchard: Nothing to Disclose, Delphine Weil-Verhoeven: Nothing to Disclose, Vincent Di Martino: Nothing to Disclose, Aicha Demidem: Nothing to Disclose, Armand Abergel: Nothing to Disclose 1875 RADIOMICS-BASED PREDICTION OF HCC RESPONSE TO ATEZOLIZUMAB/BEVACIZUMAB Isaac Israel Rodriguez Salazar 1 Andreas Teufel 1 Abhinay Vellala 1 Timo Itzel 1 Jimmy Daza 1 Michael Vcha 1 Manuel Debic 2 De-Hua Chang 3 Michael Dill 2 Max Seidensticker 4 Gerd Oswald Stefan Schnberg 1 Lukas Mller 5 Julia Mayerle 4 Stefan Munker 4 Peter Galle 5 Arndt Weinmann 5 Dietmar Tamandl 6 Matthias Pinter 6 Marino Venerito 7 Matthias Ebert 1 Matthias Froelich 1 Maciej Pech 7 Friedrich Sinner 7 Bernhard Scheiner 6 , 1 Medical Faculty Mannheim, 2 Medical Faculty Heidelberg, 3 Cantonal Hospital of Lucerne, 4 LMU Munich, 5 University Medical Center Mainz, 6 Medical Faculty Vienna, 7 Magdeburg University Background: Atezolizumab/ bevacizumab has emerged as a breakthrough therapy for advanced hepatocellular carcinoma (HCC)
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We used this information to design a tailored affinity maturation library for R023, aiming to decrease its dissociation rate from soto-p 7 /A*03 and A*11 while maintaining minimal competition with free sotorasib
