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B2m +/+ PEMs promptly formed membrane ruffles around beads, whereas B2m -/- PEMs did not, although polymerized actin surrounded the beads in both PEMs ( Figure 3C )

Enzyme-instructed self-assembly (EISA) and hydrogelation of peptides

Hemalatha et al., 1991

Unfortunately, skin irritation, which is most prominent in the first weeks of treatment, is associated with poor tolerability and suboptimal adherence, which reduces the response to treatment