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Improvement of neuronal bioenergetics by neurosteroids: implications for age-related neurodegenerative disorders

10 Ovarian reserve declines gradually as follicles degrade with age

It is noteworthy that the conversion of the *OOH intermediate to generate *OO and *H remains a high-energy barrier in Ru-oxide, whereas it proceeds spontaneously in Ru-hydroxide due to the reprotonation process of the hydroxide substrate (Fig