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Skin -synuclein aggregation seeding activity as a novel biomarker for Parkinson Disease

Schnellmann et al

For instance, biomarkers such as high PHGDH expression, IDH2 status and Parkin deficiency can be utilized to identify patient populations most likely to benefit from SSP-targeted therapy

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The FDAs green light was based on results from the Phase III CAPItello-291 where the combination cut the risk of disease progression or death by half compared to Faslodex alone